Association of the IFNL4-ΔG Allele With Impaired Spontaneous Clearance of Hepatitis C Virus
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چکیده
منابع مشابه
Association of the IFNL4-ΔG Allele With Impaired Spontaneous Clearance of Hepatitis C Virus.
Interferon lambda 4 protein can be generated in IFNL4-ΔG carriers but not IFNL4-TT homozygotes. We studied 890 anti-hepatitis C virus (HCV)-positive participants in the Women's Interagency HIV Study. Among blacks (n = 555), HCV was more often cleared for those with genotype IFNL4-TT/TT (32.6%; odds ratio [OR], 3.59; P = 3.3 × 10(-5)) than IFNL4-TT/ΔG (11.3%; OR, 0.95; P = .86) or IFNL4-ΔG/ΔG (1...
متن کاملthe impact of ifnl4 rs12979860 polymorphism on spontaneous clearance of hepatitis c; a case-control study
materials and methods a case-control study was designed on 91 cases with spontaneous hcv infection clearance and 259 patients with persistent hcv infection as the control group. the rs12979860 snp was assessed as the most common ifnl polymorphism by pcr-rflp method. results distribution of rs12979860 cc genotype in the spontaneous clearance group was around two folds of its distribution in chro...
متن کاملThe Impact of IFNL4 rs12979860 Polymorphism on Spontaneous Clearance of Hepatitis C; A Case-Control Study
BACKGROUND About 30% of individuals with hepatitis C virus (HCV) infection are able to clear HCV spontaneously. Differences in host genetics affect the outcome of HCV infection. Single nucleotide polymorphisms (SNPs) of the Interferon lambda (IFNL) genes were associated with spontaneous and treatment-induced clearance of HCV infection. OBJECTIVES The aim of this study was to evaluate the asso...
متن کاملAssociation with Spontaneous Hepatitis C Viral Clearance and Genetic Differentiation of IL28B/IFNL4 Haplotypes in Populations from Mexico
AIM To analyze the genetic heterogeneity of the Amerindian and admixed population (Mestizos) based on the IL28B (rs12979860, rs8099917) and IFNL4 (rs368234815) haplotypes, and their association with spontaneous clearance (SC) and liver damage in patients with hepatitis C infection from West Mexico. METHODS A total of 711 subjects from West Mexico (181 Amerindians and 530 Mestizos) were studie...
متن کاملAssociation of HLA-DQ and IFNL4 polymorphisms with susceptibility to hepatitis B virus infection and clearance.
UNLABELLED Background and aim. Leukocyte antigen DQ (HLA-DQ) and interferon-λ4 (IFNL4) gene polymorphisms were associated with susceptibility to chronic hepatitis B and C virus infection. This study further confirmed that variants of these genes were associated with susceptibility and spontaneous clearance of HBV infection in a Chinese population. MATERIAL AND METHODS A total of 1,069 subjec...
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ژورنال
عنوان ژورنال: The Journal of Infectious Diseases
سال: 2013
ISSN: 1537-6613,0022-1899
DOI: 10.1093/infdis/jit433